Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study.

Nádia Calvo Martins OkuyamaFernando Cezar-Dos-SantosÉrica Romão PereiraKleber Paiva TrugiloGuilherme Cesar Martelossi CebinelliMichelle Mota SenaAna Paula Lombardi PereiraAdriano Martin Felis AranomeLuis Fernando Lasaro MangieriRodolfo Sanches FerreiraMaria Angelica Ehara WatanabeKaren Brajão de Oliveira

Published in: Journal of biomedical science (2018)

In the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development.

Keyphrases

high grade
low grade
genome wide
copy number
gene expression
transcription factor