Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE2 production.
Bruna M SantosHeloísa D C FrancescatoFlávia C TurcatoJosé Antunes-RodriguesTerezila M CoimbraLuiz G S BrancoPublished in: Acta physiologica (Oxford, England) (2019)
Endotoxin tolerance is not simply a reflection of peripheral reduced cytokines release but actually results from a complex set of mechanisms acting at multiple levels. Hypothalamic H2 S production modulates most of these mechanisms.
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