Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.

Naofumi KajitaniMasaaki IwataAkihiko MiuraKyohei TsunetomiTakehiko YamanashiRyoichi MatsuoTsuyoshi NishiguchiSaki FukudaMayu NagataMidori ShibushitaTakahira YamauchiShenghong PuYukihiko ShirayamaKen WatanabeKoichi Kaneko

Published in: Neuropsychopharmacology reports (2020)

BHB may be a novel therapeutic candidate for the treatment of depression based on the neuro-inflammatory hypothesis, and the PFC is a region implicated in the antidepressant action of BHB.

Keyphrases

nlrp inflammasome
prefrontal cortex
major depressive disorder
depressive symptoms
sleep quality
oxidative stress
low dose
bipolar disorder
replacement therapy