Tc-99m labelled bone scintigraphy in suspected cardiac amyloidosis.
Muhammad Umaid RaufPhilip N HawkinsFrancesco CappelliFederico PerfettoMattia ZampieriAlessia ArgiroAviva PetrieSteven LawAldostefano PorcariYousuf RazviJoshua BomsztykSriram RavichandranAdam IoannouRishi K PatelNeasa StarrDavid F HuttShameem MahmoodBrendan WisniowskiAna Martinez-NaharroLucia VenneriCarol WhelanDorota RoczenioJanet GilbertsonHelen J LachmannAshutosh D WechalekarClaudio RapezziMatteo SerenelliPaolo MassaAngelo Giuseppe CaponettiAlberto PonzianiAntonella AcciettoAlessandro GiovannettiGiulia SaturiMaurizio SguazzottiChristian GagliardiElena BiaginiSimone LonghiMarianna FontanaJulian D GillmorePublished in: European heart journal (2023)
The NBDC for ATTR-CM are highly specific [97% (95% CI 0.91-0.99)] in clinical setting, and diagnostic performance was further refined here using new cut-offs for sFLC ratio in patients with CKD. A grade 0 radionuclide scan all but excludes ATTR-CM but occurs in most patients with AL-CA. Grade 1 scans in patients with CA and no MG are strongly suggestive of early ATTR-type, but require urgent histologic corroboration.