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EphA3 CAR T cells are effective against glioblastoma in preclinical models.

Jose Paulo MartinsRochelle C J D'SouzaNiclas SkarneLea LekieffreShane HorsefieldMadusha RanjankumarXiang LiThuy T LeFiona SmithCorey SmithJacqueline BurrowsBryan W DayRajiv Khanna
Published in: Journal for immunotherapy of cancer (2024)
This study provides compelling evidence supporting the therapeutic potential of EphA3 CAR T-cell therapy against glioblastoma by targeting EphA3 associated with brain cancer stem cells and the tumor vasculature. The ability to target patient-derived glioblastoma underscores the translational significance of this EphA3 CAR T-cell therapy in the pursuit of effective and targeted glioblastoma treatment strategies.
Keyphrases
  • cell therapy
  • stem cells
  • mesenchymal stem cells
  • cancer stem cells
  • cancer therapy
  • bone marrow
  • drug delivery
  • brain injury
  • cerebral ischemia