Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study.

Olaf PenackThomas LuftChristophe PeczynskiAxel BennerSimona SicaMutlu AratMaija Itäla-RemesLucia López CorralNicolaas P M SchaapMichal KarasLudek RaidaThomas SchroederPeter DregerElisabetta MetafuniTulay OzcelikBrenda M SandmaierLambros KordelasIvan MoiseevHélène SchoemansChristian KoeneckeGrzegorz W BasakZinaida Peric

Published in: Journal for immunotherapy of cancer (2024)

The results of this study provide a prospectively validated standard laboratory biomarker index to estimate the transplant-related mortality risk after alloSCT. EASIX ≥3 taken before conditioning identifies a population of alloSCT recipients who have a more than twofold increased risk of treatment-related mortality.

Keyphrases

stem cell transplantation
high dose
genome wide
low dose
endothelial cells
cardiovascular disease
bone marrow
risk factors
hematopoietic stem cell
smoking cessation