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Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study.

Olaf PenackThomas LuftChristophe PeczynskiAxel BennerSimona SicaMutlu AratMaija Itäla-RemesLucia López CorralNicolaas P M SchaapMichal KarasLudek RaidaThomas SchroederPeter DregerElisabetta MetafuniTulay OzcelikBrenda M SandmaierLambros KordelasIvan MoiseevHélène SchoemansChristian KoeneckeGrzegorz W BasakZinaida Peric
Published in: Journal for immunotherapy of cancer (2024)
The results of this study provide a prospectively validated standard laboratory biomarker index to estimate the transplant-related mortality risk after alloSCT. EASIX ≥3 taken before conditioning identifies a population of alloSCT recipients who have a more than twofold increased risk of treatment-related mortality.
Keyphrases
  • stem cell transplantation
  • high dose
  • genome wide
  • low dose
  • endothelial cells
  • cardiovascular disease
  • bone marrow
  • risk factors
  • hematopoietic stem cell
  • smoking cessation