Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.

Jiao WangQiong HuangXingbin HuShuyi ZhangYu JiangGuangyu YaoKongzhen HuXin XuBishan LiangQijing WuZhenfeng MaYawen WangChunlin WangZhenzhen WuXiaoxiang RongWang-Jun Liao Min Shi

Published in: Cancer research (2022)

In trastuzumab-resistant HER2-positive gastric cancer, glycolysis fluctuates with a circadian oscillation regulated by the BMAL1-CLOCK-PER1-HK2 axis, which can be disrupted with a metformin-based chronotherapy to overcome trastuzumab resistance.

Keyphrases

epidermal growth factor receptor
metastatic breast cancer
high glucose
tyrosine kinase
atrial fibrillation
high frequency
blood pressure
resting state
functional connectivity