Phase 1 trial of ADI-PEG20 plus cisplatin in patients with pretreated metastatic melanoma or other advanced solid malignancies.
Shuyang YaoFilip JankuVivek SubbiahJohn StewartSapna Pradyuman PatelAhmed KasebShannon Neville WestinAung NaingApostolia Maria TsimberidouDavid HongSarina Anne Piha-PaulNai ShiAmanda JohnstonJohn BomalaskiSiqing FuPublished in: British journal of cancer (2021)
Concurrently administered ADI-PEG20 and cisplatin had an acceptable safety profile and had shown antitumour activity against metastatic ASS1-deficient solid tumours. Further evaluation of this treatment combination is warranted.