Cooperative Response to Endocardial Notch Reveals Interaction With Hippo Pathway.

Luis Luna-Zurita Brenda Giselle Flores-GarzaDimitrios GrivasMarcos Siguero-Álvarez José Luis de la Pompa

Published in: Circulation research (2023)

Sequential Notch-dependent transcriptional regulation in the embryonic endocardium involves multiple factors. Notch activates certain noncoding elements through these factors and simultaneously suppresses elements that could hinder cardiac valve development and homeostasis. Biorxviv: https://www.biorxiv.org/content/10.1101/2023.03.23.533882v1.full.

Keyphrases

cell proliferation
aortic valve
mitral valve
left ventricular
signaling pathway
heart failure
aortic stenosis