Disease Severity Linked to Increase in Autoantibody Diversity in IgG4-Related Disease.

Hang LiuCory A PeruginoMusie GhebremichaelZachary Scott WallaceSydney B MontesiJohn H Stone Shiv S Pillai

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Antibodies against prohibitin, annexin A11, and laminin 511-E8 were found in only a small portion of patients with IgG4-RD. A subset of IgG4-RD patients, however, had IgG4 antibodies against ≥2 autoantigens. These patients presented with robust IgG subclass elevations, complement consumption, and visceral organ involvement. This broader break in immunologic tolerance in IgG4-RD was associated with more severe disease.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
type diabetes
metabolic syndrome
adipose tissue
patient reported outcomes
early onset