Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer.

Andreas BrøndenKristian MikkelsenDavid P SonneMorten HansenChristoffer VåbenMaria N GabeMette RosenkildeValentina TremaroliHao WuFredrik BäckhedJens F RehfeldJens J HolstTina Vilsbøll Filip K Krag Knop

Published in: Diabetes, obesity & metabolism (2018)

Sevelamer reduced plasma glucose concentrations in patients with type 2 diabetes by mechanisms that seemed to involve decreased intestinal and hepatic bile acid-mediated farnesoid X receptor activation.

Keyphrases

blood glucose
type diabetes
blood pressure
metabolic syndrome
binding protein