Dual-trajectories of opioid and gabapentinoid use and risk of subsequent drug overdose among Medicare beneficiaries in the United States: a retrospective cohort study.

Lili Zhou Sandipan Bhattacharjee Chian K KwohPatrick J TigheGary M ReisfieldDaniel C MaloneMarion SlackDebbie L Wilson Ching-Yuan Chang Wei-Hsuan Lo-Ciganic

Published in: Addiction (Abingdon, England) (2020)

Risk of drug overdose varied substantially among US Medicare beneficiaries on different use trajectories of opioids and gabapentinoids. High-dose opioid-only users and all consistent opioid and gabapentinoid users (regardless of doses) had more than double the risk of subsequent drug overdose compared with opioid-only early discontinuers.

Keyphrases

chronic pain
pain management
high dose
depressive symptoms
low dose
adverse drug
drug induced
emergency department
electronic health record