Heterocyclic iodoniums as versatile synthons to approach diversified polycyclic heteroarenes.
Daqian ZhuZhouming WuLiyun LiangYameng SunBingling LuoPeng HuangShijun WenPublished in: RSC advances (2019)
Polycyclic heteroarenes are important scaffolds in the construction of pharmaceuticals. We have previously developed a series of novel heterocyclic iodoniums. In our current work, these unique iodoniums were employed to construct various complex polycyclic heteroarenes with structural diversity via tandem dual arylations. As a result, indole, thiophene and triphenylene motifs were fused into these heterocycles with high molecular quality, which might provide promising fragments in drug discovery. Moreover, these heterocycles could be diversified at a late stage.
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