Cellular mechanisms involved in the pathogenesis of airway remodeling in chronic lung disease.

E Arellano-OrdenC Calero AcuñaV Sánchez-LópezC López RamírezR Otero-CandeleraC Marín-HinojosaJosé Luis López-Campos

Published in: European clinical respiratory journal (2022)

The lung fibroblasts seem to be the main initially stimulated cells that could potentially trigger the inflammatory response, and be responsible for the eventual onset of chronic lung disease. The involvement of IL-1ß stimulation in systemic inflammatory and proteinase imbalance biomarkers is higher in lung fibroblasts. Apoptosis is not a predominant mechanism in these cells.

Keyphrases

cell cycle arrest
induced apoptosis
inflammatory response
endoplasmic reticulum stress
oxidative stress
cell death
pi k akt
toll like receptor
immune response
drug induced
lps induced