A novel role of DOT1L in kidney diseases.

Wei WeiYibo ZhaoYanfen ChaiSongtao ShouHeng Jin

Published in: Molecular biology reports (2023)

A better understanding of DOT1L as a histone methylase based on characteristics of regulating telomere silencing, transcriptional extension, DNA damage repair and cell cycle could lead to the development of new therapeutic targets for various kidney diseases, thereby improving the prognosis of kidney disease patients.

Keyphrases

cell cycle
dna damage
end stage renal disease
cell proliferation
peritoneal dialysis
transcription factor
dna methylation
oxidative stress
energy transfer