Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction.
Fang-Fei WeiSander TrensonPierre MonneyWen-Yi YangMenno PruijmZhen-Yu ZhangYassine BouatouQi-Fang HuangBelen PontePierre-Yves MartinLutgarde ThijsTatiana KuznetsovaKarel AllegaertStefan JanssensCees VermeerPeter VerhammeMichel BurnierMurielle BochudGeorg EhretJan A StaessenPublished in: PloS one (2018)
Our study supports a role of activated MGP in maintaining myocardial integrity and diastolic LV performance and can potentially be translated into new strategies for managing diastolic LV dysfunction and preventing its progression to heart failure.