Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.

Florent BarryFeng ChaiHenry Chijcheapaza-FloresMaria José Garcia-FernandezNicolas BlanchemainRomain Nicot

Published in: PloS one (2023)

MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs.

Keyphrases

chronic pain
high glucose
neuropathic pain
rheumatoid arthritis
pain management
high resolution
spinal cord
knee osteoarthritis
mass spectrometry
photodynamic therapy
fluorescence imaging