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The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Shipeng Li
Ping Yang
Zhenghan Wu
Wenqiang Huang
Xiaofeng Zhu
Lianmei Zhong
Published in:
Brain research bulletin (2024)
Our study demonstrates for the first time that AM1241 alleviates mouse CIRI by inhibiting the MD2/TLR4 complex, exerting anti-inflammatory, anti-oxidative stress and anti-apoptotic effects.
Keyphrases
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oxidative stress
ischemia reperfusion injury
anti inflammatory
cell death
toll like receptor
dna damage
subarachnoid hemorrhage
cerebral ischemia
cerebral blood flow