Chemotherapy and biologic use in the routine management of metastatic colorectal cancer in Australia: is clinical practice following the evidence?
Christine SemiraHui-Li WongKathryn FieldMargaret LeeBelinda LeeLouise NottJeremy ShapiroRachel WongJeanne TieBen TranGary RichardsonAllan ZimetLara LiptonBabak TamjidMatthew BurgeBrigette MaJulie JohnsMichael HaroldPeter GibbsPublished in: Internal medicine journal (2020)
Doublet chemotherapy + bevacizumab remains the dominant initial strategy, with limited uptake of triplet chemotherapy and of EGFRi. Potential explanations include uncertainty about the significance of post hoc analyses for EGFRi and concerns regarding adverse events for both strategies.