Microbiota Composition and Metabolism Are Associated With Gut Function in Parkinson's Disease.
Mihai S CirsteaAdam C YuElla GolzKristen SundvickDaniel KligerNina RadisavljevicLiam H FoulgerMelissa MackenzieTau HuanB Brett FinlaySilke Appel-CresswellPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
Compositional and metabolic alterations in the Parkinson's microbiota are highly associated with gut function, suggesting plausible mechanistic links between altered bacterial metabolism and reduced gut health in this disease. The systemic detection of elevated deleterious proteolytic microbial metabolites in Parkinson's serum suggests a mechanism whereby microbiota dysbiosis contributes to disease etiology and pathophysiology. © 2020 International Parkinson and Movement Disorder Society.