Enhanced cell survival and therapeutic benefits of IL-10-expressing multipotent mesenchymal stromal cells for muscular dystrophy.
Yuko Nitahara-KasaharaMutsuki KuraokaYuki OdaHiromi Hayashita-KinohShin'ichi TakedaTakashi OkadaPublished in: Stem cell research & therapy (2021)
In case of local injection, IL-10-MSCs could maintain the long-term engraftment status and facilitate associated tissue repair. In case of repeated systemic administration, IL-10-MSCs facilitated the long-term retention of the cells in the skeletal muscle and also protected muscles from physical damage-induced injury, which improved muscle dysfunction in DMD. We can conclude that the local and systemic administration of IL-10-producing MSCs offers potential benefits for DMD therapy through the beneficial paracrine effects of IL-10 involving SDF-1.
Keyphrases
- muscular dystrophy
- skeletal muscle
- mesenchymal stem cells
- duchenne muscular dystrophy
- oxidative stress
- induced apoptosis
- physical activity
- type diabetes
- drug induced
- mental health
- insulin resistance
- diabetic rats
- cell cycle arrest
- endothelial cells
- cell proliferation
- signaling pathway
- cell death
- cell therapy
- ultrasound guided
- human health
- wild type