MSCs-exosomes can promote macrophage M2 polarization via exosomal miR-21-5p through Mesenteric injection: a promising way to attenuate murine colitis.

Wenwei QianEnhao WuHong ChenJun YaoJin WangYudi ZhouYanjin BaiSheng WangChen ShenYi LiYi Zhang

Published in: Journal of Crohn's & colitis (2024)

Mesenteric injection of HucMSCs-Exos significantly alleviates mesenteric inflammation and colitis by promoting mesenteric macrophage M2 polarization, making it a promising approach to treat colitis and suggesting therapeutic potential role of exosomal miR-21-5p in CD.

Keyphrases

mesenchymal stem cells
adipose tissue
ulcerative colitis
oxidative stress
stem cells
ultrasound guided