Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study.
Steven D ForsytheRichard A EraliShyama SasikumarPreston LaneyEthan ShelkeyRalph D'AgostinoLance D MillerPerry ShenEdward A LevineShay SokerKonstantinos I VotanopoulosPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Immunotherapy shows measurable efficacy in appendiceal cancer organoids. Information derived from immunocompetent organoids may be applied in selecting patients for clinical trial enrollment in rare diseases where preclinical models of disease are lacking.
Keyphrases
- papillary thyroid
- clinical trial
- low grade
- end stage renal disease
- squamous cell
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cell therapy
- healthcare
- stem cells
- squamous cell carcinoma
- young adults
- high throughput
- health insurance
- lymph node metastasis
- childhood cancer
- mesenchymal stem cells
- double blind
- induced pluripotent stem cells
- high grade