Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.

Erika J Crosby William R GwinKimberly BlackwellP Kelly MarcomSerena ChangHolden T MaeckerGloria BroadwaterTerry HyslopSungjin KimAndre RogatkoVeronica LubkovJoshua C SnyderTakuya OsadaAmy C HobeikaMichael A MorseHerbert Kim Lyerly Zachary Conrad Hartman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

VRP-HER2 increased HER2-specific memory CD8 T cells and had antitumor effects in preclinical and clinical studies. The expansion of HER2-specific memory CD8 T cells in vaccinated patients was significantly correlated with increased PFS. Subsequent studies will seek to enhance T-cell activity by combining with anti-PD-1.

Keyphrases

working memory
end stage renal disease
endothelial cells
newly diagnosed
ejection fraction
chronic kidney disease
high glucose
peritoneal dialysis
patient reported outcomes
cell therapy
bone marrow
oxidative stress
mesenchymal stem cells
young adults
case control
patient reported