Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons.

Jamin LiuMatthew T LaurieLuis RubioSara E VazquezSara SunshineAnthea M MitchellMatthias Hapte-SelassieSabrina A MannGenay PilarowskiDouglas BlackCarina MarquezSusana RojasMichail S LionakisMaya L PetersenJeffrey D WhitmanVivek JainMark AndersonDiane HavlirJoseph DeRisi

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination "breakthrough" COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
immune response
dendritic cells
optical coherence tomography
inflammatory response