Alpha1-Adrenoceptor Antagonists Improve Memory by Activating N-methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus.

Chang Hee KimIl Gyu KoSung Eun KimMal Soon ShinYeon Ho KangJung Wan ChoKey Moon ShinChang Ju KimBaek Vin LimKhae Hawn Kim

Published in: International neurourology journal (2015)

Tamsulosin enhanced memory function by activating NMDA receptor-mediated ion currents in the hippocampus without initiating apoptosis. The present study suggests the possibility of using tamsulosin to enhance memory under normal conditions, in addition to its use in treating overactive bladder.

Keyphrases

working memory
oxidative stress
signaling pathway
benign prostatic hyperplasia
lower urinary tract symptoms
diabetic rats
endoplasmic reticulum stress
cell death
cerebral ischemia
prefrontal cortex
cell cycle arrest
brain injury
blood brain barrier