Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo .
Hong LiangZhike YanYuhong TongShan ChenJing-Ying LiLanlan ChenHuang-Hao YangPublished in: Chemical communications (Cambridge, England) (2023)
We developed a circular bivalent aptamer (CBA) to precisely activate membrane receptor-mediated regenerative signaling for liver repair in vivo . The CBA showed enhanced biostability and receptor binding avidity, achieving effective pathway activation and satisfactory treatment in an acetaminophen-induced liver injury model. This work expands aptamer-based molecular engineering in regenerative medicine.
Keyphrases
- liver injury
- drug induced
- stem cells
- mesenchymal stem cells
- signaling pathway
- gold nanoparticles
- cell therapy
- sensitive detection
- tissue engineering
- pi k akt
- magnetic nanoparticles
- epithelial mesenchymal transition
- label free
- combination therapy
- oxidative stress
- single molecule
- bone marrow
- transcription factor
- replacement therapy
- dna binding
- nucleic acid
- smoking cessation