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Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression.

Nobuo HorikoshiPankaj KumarGirdhar G SharmaMin ChenClayton R HuntKenneth WestoverShantanu ChowdhuryTej K Pandita
Published in: Genome integrity (2013)
The results suggest that H4K16 acetylation has a limited effect on transcription regulation in HEK293 cells, whereas H4K16ac has been demonstrated to have critical roles in regulating transcription in mouse embryonic stem cells. Thus, H4K16ac-dependent transcription regulation is likely a cell type specific process.
Keyphrases
  • embryonic stem cells
  • gene expression
  • genome wide
  • dna methylation
  • transcription factor
  • induced apoptosis
  • cell cycle arrest
  • histone deacetylase
  • cell death
  • signaling pathway
  • endoplasmic reticulum stress