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Roles of impaired intracellular calcium cycling in arrhythmogenicity of diabetic mouse model.

Chung-Chuan ChouChien-Te HoHui-Ling LeeYen ChuTzung-Hai YenMing-Shien WenShien-Fong LinCheng-Hung LeeChun-Chieh Wang
Published in: Pacing and clinical electrophysiology : PACE (2017)
The type 2 diabetic mouse hearts show impaired repolarization, Cai handling homeostasis, and cardiac conduction reserve, leading to vulnerability of spatially discordant alternans development and induction of VA. Altered Cai -handling protein expressions probably underlie the molecular mechanisms of arrhythmogenicity in the type 2 diabetes animal model.
Keyphrases
  • type diabetes
  • mouse model
  • wound healing
  • glycemic control
  • climate change
  • cardiovascular disease
  • left ventricular
  • high intensity
  • reactive oxygen species
  • metabolic syndrome