Roles of impaired intracellular calcium cycling in arrhythmogenicity of diabetic mouse model.

Chung-Chuan ChouChien-Te HoHui-Ling LeeYen ChuTzung-Hai YenMing-Shien WenShien-Fong LinCheng-Hung LeeChun-Chieh Wang

Published in: Pacing and clinical electrophysiology : PACE (2017)

The type 2 diabetic mouse hearts show impaired repolarization, Cai handling homeostasis, and cardiac conduction reserve, leading to vulnerability of spatially discordant alternans development and induction of VA. Altered Cai -handling protein expressions probably underlie the molecular mechanisms of arrhythmogenicity in the type 2 diabetes animal model.

Keyphrases

type diabetes
mouse model
wound healing
glycemic control
climate change
cardiovascular disease
left ventricular
high intensity
reactive oxygen species
metabolic syndrome