Hemicyanine-Based Near-Infrared Activatable Probes for Imaging and Diagnosis of Diseases.
Ziling ZengSi Si LiewXin WeiKanyi PuPublished in: Angewandte Chemie (International ed. in English) (2021)
Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the construction of activatable optical probes. This Review presents a survey of hemicyanine-based NIR activatable probes (HNAPs) for in vivo imaging and early diagnosis of diseases. The molecular design principles of HNAPs towards activatable optical signaling against various biomarkers are discussed with a focus on their broad applications in the detection of diseases including inflammation, acute organ failure, skin diseases, intestinal diseases, and cancer. This progress not only proves the unique value of HNAPs in preclinical research but also highlights their high translational potential in clinical diagnosis.
Keyphrases
- fluorescence imaging
- photodynamic therapy
- fluorescent probe
- living cells
- high resolution
- single molecule
- small molecule
- oxidative stress
- emergency department
- energy transfer
- stem cells
- risk assessment
- liver failure
- drug delivery
- intensive care unit
- drug release
- drug induced
- aortic dissection
- electronic health record
- nucleic acid
- respiratory failure
- mesenchymal stem cells
- sensitive detection
- loop mediated isothermal amplification