DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus.

Pault Y M FerruzoViktor K BoellLilian C RussoCarla C OliveiraFabio Luis Forti

Published in: Biology of the cell (2024)

Overall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC-ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM-domain proteins.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
oxidative stress
signaling pathway
amino acid
pi k akt
structural basis