Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice.
Xuan SunSarah M BernhardtDanielle J GlynnLeigh J HodsonLucy WoolfordAndreas EvdokiouCong YanHong DuSarah A RobertsonWendy V IngmanPublished in: Breast cancer research : BCR (2021)
TGFB acts on macrophage populations in the mammary gland to reduce their abundance and dampen the inflammatory phenotype. TGFB signalling in macrophages increases mammary cancer susceptibility potentially through suppression of immune surveillance activities of macrophages.