The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A.
Iwona AdwentBeniamin Oskar GrabarekMarta Kojs-MrożkiewiczRyszard BrusRafał StaszkiewiczAndrzej PlewkaMichał Jan StasiowskiAnita Lyssek-BoronPublished in: Mediators of inflammation (2020)
Analysis of the microarray expression profile of genes associated with TGFβ signaling pathways has demonstrated the potential of cyclosporin A and adalimumab to induce changes in their transcriptional activity. The anti-TNF drug seems to affect TGFβ cascades to a greater extent than cyclosporin A. The obtained results suggest that the regularity of taking the drug is important for the efficacy of psoriasis therapy.
Keyphrases
- transforming growth factor
- rheumatoid arthritis
- signaling pathway
- induced apoptosis
- epithelial mesenchymal transition
- pi k akt
- juvenile idiopathic arthritis
- cell cycle arrest
- toll like receptor
- endoplasmic reticulum stress
- transcription factor
- gene expression
- inflammatory response
- ulcerative colitis
- oxidative stress
- bioinformatics analysis
- adverse drug
- stem cells
- disease activity
- systemic lupus erythematosus
- dna methylation
- mesenchymal stem cells
- cell therapy
- genome wide identification
- atopic dermatitis
- replacement therapy