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Tyrosine kinase inhibitors in the treatment of metastatic renal cell cancer patients with early cytokine intolerance: TURCOS, a Turkish national, prospective observational study.

Mustafa BenekliMahmut GumusMetin OzkanFaysal DaneEmin T ElkiranIrfan CicinAlper SevincMehmet AliustaogluAbdurrahman IsikdoganNezih MeydanBerna OksuzogluOzgur OzyilkanMustafa YıldırımFeyyaz OzdemirSadettin Kilickap
Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)
Our findings confirm the efficacy and safety profile of TKIs in the first-line treatment of mRCC patients intolerant to cytokine treatment. There was no significant difference among three TKI agents in terms of treatment duration, ORR, PFS and OS.Trial registration: TURCOS ClinicalTrials.gov Identifier: NCT01585974. Registered April 25, 2012.
Keyphrases
  • small cell lung cancer
  • squamous cell carcinoma
  • clinical trial
  • cell therapy
  • quality improvement
  • advanced non small cell lung cancer
  • epidermal growth factor receptor
  • chronic myeloid leukemia
  • double blind