Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia.

Jesse C DeSimoneWei-En WangDavid A LoewensteinRanjan DuaraGlenn E SmithKaren N McFarlandMelissa J ArmstrongDarren M WeberWarren BarkerStephen A CoombesDavid E Vaillancourt

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Plasma Aβ42/40 positivity is associated with brain microstructure decline. Plasma+/PET- demonstrated increased FW in 24 total GM and WM regions. Plasma+/PET- demonstrated decreased FAt in 66 total GM and WM regions. Whole-brain FW correlated with plasma Aβ42/40 and p-tau181 measures. Plasma+/PET- demonstrated decreased cortical volume and thickness.

Keyphrases

computed tomography
pet ct
positron emission tomography
white matter
magnetic resonance imaging
pet imaging
adipose tissue
resting state
multiple sclerosis
cerebrospinal fluid