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Doxorubicin and Quercetin Double Loading in Modified MCM-41 Lowered Cardiotoxicity in H9c2 Cardioblast Cells In Vitro.

Christina VoychevaTeodora PopovaMarta SlavkovaVirginia TzankovaDenitsa StefanovaDiana TzankovaIvanka SpassovaDaniela KovachevaBorislav Tzankov
Published in: Bioengineering (Basel, Switzerland) (2023)
A successful procedure was proposed for the efficient double loading of a hydrophilic drug and a hydrophobic drug. The carboxy-modified double-loaded nanosystems demonstrate a decreased in vitro cardiotoxicity of doxorubicin and can be considered as a potential chemotherapeutic formulation.
Keyphrases
  • drug delivery
  • cancer therapy
  • induced apoptosis
  • adverse drug
  • drug induced
  • liquid chromatography
  • oxidative stress
  • cell proliferation
  • high resolution