Doxorubicin and Quercetin Double Loading in Modified MCM-41 Lowered Cardiotoxicity in H9c2 Cardioblast Cells In Vitro.

Christina VoychevaTeodora PopovaMarta SlavkovaVirginia TzankovaDenitsa StefanovaDiana TzankovaIvanka Spassova Daniela KovachevaBorislav Tzankov

Published in: Bioengineering (Basel, Switzerland) (2023)

A successful procedure was proposed for the efficient double loading of a hydrophilic drug and a hydrophobic drug. The carboxy-modified double-loaded nanosystems demonstrate a decreased in vitro cardiotoxicity of doxorubicin and can be considered as a potential chemotherapeutic formulation.

Keyphrases

drug delivery
cancer therapy
induced apoptosis
adverse drug
drug induced
liquid chromatography
oxidative stress
cell proliferation
high resolution