Targeting Echinococcus multilocularis PIM kinase for improving anti-parasitic chemotherapy.
Akito KoikeFrank BeckerPeter SennhennJason KimJenny ZhangStefan HannusKlaus BrehmPublished in: PLoS neglected tropical diseases (2022)
Repurposing of kinase inhibitors initially designed to affect mammalian kinases for helminth disease treatment is often hampered by adverse side effects of respective compounds on human cells. Here we demonstrate the utility of high throughput in silico approaches to design small molecule compounds of higher specificity for parasite cells. We propose EmPim as a promising target for respective approaches towards AE treatment.
Keyphrases
- small molecule
- high throughput
- induced apoptosis
- emergency department
- cell proliferation
- tyrosine kinase
- molecular docking
- cell death
- single cell
- oxidative stress
- locally advanced
- cell cycle arrest
- endoplasmic reticulum stress
- molecular dynamics simulations
- rectal cancer
- pi k akt
- trypanosoma cruzi
- life cycle
- plasmodium falciparum