Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry.

Warunee HanpithakpongNicholas P J DayNicholas J WhiteJoel Tarning

Published in: Malaria journal (2022)

Simple, sensitive and accurate LC-MS/MS methods for the quantification of enantiomeric and racemic primaquine and carboxyprimaquine in human plasma were validated successfully and implemented in clinical routine drug analysis.

Keyphrases

liquid chromatography tandem mass spectrometry
simultaneous determination
ms ms
solid phase extraction
clinical practice
high resolution
emergency department
drug induced
adverse drug
capillary electrophoresis
data analysis