Reversing the mitochondrial hex that bewitches NLRP3.

Manasa MellacheruvuGrace M E P LawrenceStefan Emming Kate Schroder

Published in: Science immunology (2023)

Hexokinase dissociation from mitochondria triggers calcium-induced oligomerization of VDAC within the outer mitochondrial membrane, leading to NLRP3 recruitment and inflammasome signaling (see related Research Article by Baik et al. ).

Keyphrases

oxidative stress
diabetic rats
high glucose
nlrp inflammasome
cell death
drug induced
endoplasmic reticulum