Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways.

Arshi KhanamAlip GhoshJoel V ChuaShyam Kottilil

Published in: Journal of translational medicine (2023)

CCR4 blockade reconstitutes antiviral immune response in T cells and limits the immunosuppressive functions of Tregs, representing them as a promising immunotherapeutic target for functional cure of CHB.

Keyphrases

immune response
dendritic cells
end stage renal disease
regulatory t cells
ejection fraction
prognostic factors
transcription factor
hepatitis b virus
chronic kidney disease
toll like receptor
inflammatory response