AMP-activated protein kinase (AMPK) activator drugs reduce mechanical allodynia in a mouse model of low back pain.

Vaskar DasJeffrey S KroinMario MoricRobert J McCarthyAsokumar Buvanendran

Published in: Regional anesthesia and pain medicine (2019)

Lumbar disc puncture in mice produces consistent mechanical hypersensitivity, and postinjury treatment with AMPK activator drugs (indirect and direct) reduces the mechanical hypersensitivity.

Keyphrases

protein kinase
mouse model
drug induced
nuclear factor
skeletal muscle
minimally invasive
neuropathic pain
type diabetes
adipose tissue
metabolic syndrome
high fat diet induced
immune response
ultrasound guided