Flavonostilbenes Isolated from the Stems of Rhamnoneuron balansae as Potential SIRT1 Activators.
Hyo Moon ChoMi ZhangEun-Jin ParkBa Wool LeeYeon-Joo ParkHyun Woo KimHa-Thanh-Tung PhamYoung-Won ChinWon Keun OhPublished in: Journal of natural products (2022)
The cumulative effects of cell damage result in aging, which gradually decreases human function in various aspects and leads to multiple age-related chronic diseases. To overcome the adverse effects of aging, silent mating type information regulation 2 homologue (SIRT1) activators are promising bioactive compounds that mimic calorie restriction to improve quality of life and prevent aging. In this study, 11 new flavonostilbenes ( 1 - 11 ) and three known compounds ( 12 - 14 ) were purified from stems of Rhamnoneuron balansae . The structures of the new compounds were determined using extensive data from spectroscopic methods, including NMR and HRESIMS. Their absolute configurations were deduced by ECD calculations with coupling constant analysis. All of the isolated new compounds ( 1 - 11 ) were evaluated for their effects on SIRT1 deacetylase activity, the NAD + /NADH ratio, and the AMP-activated protein kinase activation level in cell-based assays. The results showed that rhamnoneuronal D ( 1 ) exhibits promising biological activity in several in vitro models related to SIRT1 and suggest it is a potential natural-product-based antiaging agent.
Keyphrases
- oxidative stress
- protein kinase
- ischemia reperfusion injury
- single cell
- cell therapy
- high resolution
- magnetic resonance
- molecular docking
- human health
- electronic health record
- stem cells
- risk assessment
- healthcare
- deep learning
- social media
- emergency department
- mesenchymal stem cells
- induced pluripotent stem cells
- big data
- health information
- artificial intelligence
- room temperature
- ionic liquid
- electron transfer