Haploinsufficiency of the NF1 gene is associated with protection against diabetes.

Roope A KallionpääSirkku PeltonenJussi LeppävirtaMinna PöyhönenKari AuranenHannu JärveläinenJuha Peltonen

Published in: Journal of medical genetics (2020)

Haploinsufficiency of the NF1 gene may protect against T2D and probably T1D. Since NF1 negatively regulates the Ras signalling pathway, the results suggest that the Ras pathway may be involved in the pathogenesis of diabetes.

Keyphrases

signaling pathway
lps induced
type diabetes
pi k akt
nuclear factor
cardiovascular disease
oxidative stress
copy number
glycemic control
genome wide
wild type
inflammatory response
metabolic syndrome
gene expression
dna methylation
adipose tissue
skeletal muscle
cell proliferation
toll like receptor