Mechanisms of Resistance to Tyrosine Kinase Inhibitors in ROS1 Fusion-Positive Nonsmall Cell Lung Cancer.

Xinmin ZhaoXin ZhangHanLin ChenHairong BaoXianghua WuHuijie WangHua BaoJiaohui PangSha WangJialei Wang

Published in: Clinical chemistry (2024)

This study provided a comprehensive portrait of TKI-resistance mechanisms in ROS1+ NSCLC patients. Using in silico simulations of TKI activity, novel secondary mutations that may confer TKI resistance were identified and may support clinical therapeutic decision-making.

Keyphrases

advanced non small cell lung cancer
tyrosine kinase
chronic myeloid leukemia
epidermal growth factor receptor
decision making
end stage renal disease
cell death
small cell lung cancer
ejection fraction
dna damage
newly diagnosed
single cell
prognostic factors
stem cells
molecular dynamics
cell therapy