Effects of dexmedetomidine on the function of distal organs and oxidative stress after lower limb ischaemia-reperfusion in elderly patients undergoing unilateral knee arthroplasty.
Sunshan LuXingtong ChenQian ChenZhen CahilogLili HuYan ChenJian CaoJiaolin NingBin YiKaizhi LuJianteng GuPublished in: British journal of clinical pharmacology (2021)
Intraoperative dexmedetomidine administration in elderly patients dampens the deterioration in respiratory function and suppresses the oxidative stress response in elderly patients following iatrogenic lower limb IR injury.
Keyphrases
- lower limb
- patients undergoing
- oxidative stress
- cardiac surgery
- dna damage
- minimally invasive
- signaling pathway
- middle aged
- ischemia reperfusion injury
- cerebral ischemia
- acute kidney injury
- induced apoptosis
- left ventricular
- respiratory tract
- blood brain barrier
- acute coronary syndrome
- endoplasmic reticulum stress
- percutaneous coronary intervention