Microvesicles derived from squamous cell carcinoma induce cell death, autophagy, and invasion of benign myoepithelial cells.
Elizabeth Ferreira MartinezVera Cavalcanti AraújoNatalia Festugatto NavariniIsabela Fernandes de SouzaGabriel Bernardo RenaAna Paula Dias DemasiEneida de PaulaLucas Novaes TeixeiraPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)
These findings suggest that MVs from EP modulate autophagy of Myo cells, which may, in part, explain the disappearance of these cells in in situ areas of invasive carcinoma ex-pleomorphic adenoma. Additionally, the overexpression of MMPs contributes to the development of an invasive phenotype of Myo cells, which could favor the dissolution of the basement membrane during tumorigenesis process.