Kupffer cell diversity maintains liver function in alcohol-associated liver disease.
Kyo SasakiSheetalnath B RoogeSumedha GunewardenaJanice Averilla HintzPriyanka GhoshIsabel Aranzazu Pulido RuizKyle YuquimpoMichael SchonfeldHeer MehtaHeather L StevensonOmar A SaldarriagaEsteban ArroyaveIrina TikhanovichAnn Wozniak PhDAnn WozniakSteven A WeinmanPublished in: Hepatology (Baltimore, Md.) (2024)
In this ALD model, KCs are anti-inflammatory and are critical for the maintenance of hepatocyte differentiation. Infiltrating monocytes/macrophages are largely proinflammatory and contribute more to liver fibrosis. Future targeting of specific macrophage subsets may provide new approaches to the treatment of liver failure and fibrosis in ALD.