Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response.
Yonghui HouJiyao LuanTaida HuangTiancheng DengXing LiZhifeng XiaoJiheng ZhanDan LuoYu HouLiangliang XuDingkun LinPublished in: Journal of neuroinflammation (2021)
TUDCA treatment can alleviate secondary injury and promote functional recovery by reducing oxidative stress, inflammatory response, and apoptosis induced by primary injury, and promote axon regeneration and remyelination, which could be used as a potential therapy for human SCI recovery.
Keyphrases
- oxidative stress
- inflammatory response
- spinal cord injury
- lipopolysaccharide induced
- dna damage
- induced apoptosis
- endoplasmic reticulum stress
- ischemia reperfusion injury
- stem cells
- lps induced
- endothelial cells
- cell cycle arrest
- toll like receptor
- cell death
- neuropathic pain
- risk assessment
- induced pluripotent stem cells
- heat shock
- cell proliferation
- high fat diet induced
- skeletal muscle
- climate change
- replacement therapy
- smoking cessation