Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin.
Tatsuro HitsumotoOsamu TsukamotoKen MatsuokaJunjun LiLi LiuYuki KuramotoShuichiro HigoShou OgawaNoboru FujinoShohei YoshidaHidetaka KiokaHisakazu KatoHideyuki HakuiYuki SaitoChisato OkamotoHijiri InoueJo HyejinKyoko UedaTakatsugu SegawaShunsuke NishimuraYoshihiro AsanoHiroshi AsanumaAkiyoshi TaniRiyo ImamuraShinsuke KomagawaToshio KanaiMasayuki TakamuraYasushi SakataMasafumi KitakazeJun-Ichi HarutaSeiji TakashimaPublished in: Circulation (2023)
cMLCK dysregulation contributes to the development of cardiac systolic dysfunction in humans. Our strategy to restore cMLCK activity could form the basis of a novel myotropic therapy for advanced systolic heart failure.