High prevalence of rare FBLIM1 gene variants in an Italian cohort of patients with Chronic Non-bacterial Osteomyelitis (CNO).
Adamo Pio d'AdamoAnna Monica BiancoGiovanna FerraraMartina La BiancaAntonella InsalacoAlberto TommasiniManuela PardeoMarco CattaliniFrancesco La TorreMartina FinettiClotilde AlizziGabriele SimoniniVirginia MessiaSerena PastoreRolando CimazMarco GattornoAndrea Taddionull nullPublished in: Pediatric rheumatology online journal (2020)
Considering the high frequency of rare variants in our CNO cohort, our data seem to confirm a possible role of FBLIM1 in the pathogenesis of CNO suggesting that CNO is a disorder of chronic inflammation and imbalanced bone remodeling.